A bacterial metabolite with diverse biological activities; inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of HUVECs at 5-20 µM; decreases viability of

Streptochlorin – 5 mg

Brand:
Cayman
CAS:
120191-51-7
Storage:
-20
UN-No:
Non-Hazardous - /

Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties.{46236,46237,46238,46239} It inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 20 µM.{46237} Streptochlorin (12 µg/ml) decreases viability of, as well as induces apoptosis and increases the production of reactive oxygen species (ROS) in, Hep3B human hepatocellular carcinoma cells.{46238} It does not induce cytotoxicity in RBL-2H3 mast cells at concentrations up to 100 µM.{46239} Streptochlorin prevents degranulation in antigen-stimulated mast cells, as well as inhibits Syk kinase and the Src family kinases LYN and Fyn and reduces the secretion of TNF-α and IL-4 induced by dinitrophenyl-human serum album (DNP-HSA) in RBL-2H3 mast cells. It also decreases swelling and reduces scratching behavior in a mouse model of allergic dermatitis induced by dinitrofluorobenzene (DNFB).  

 

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SKU: 27605 - 5 mg Category:

Description

A bacterial metabolite with diverse biological activities; inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of HUVECs at 5-20 µM; decreases viability of, as well as induces apoptosis and increases the production of ROS in Hep3B cells at 12 µg/ml; does not induce cytotoxicity in RBL-2H3 mast cells at concentrations up to 100 µM; prevents degranulation in antigen-stimulated mast cells, and inhibits Syk, LYN, and Fyn kinases, and reduces DNP-HSA-induced TNF-α and IL-4 secretion in RBL-2H3 mast cells; decreases swelling and reduces scratching behavior in a mouse model of DNFB-induced allergic dermatitis

Formal name: 3-(4-chloro-5-oxazolyl)-1H-indole

Synonyms:  SF 2583A

Molecular weight: 218.6

CAS: 120191-51-7

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cardiovascular System|Vasculature|Angiogenesis||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity

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