A potent inhibitor of γ-secretase (IC50 = 0.65 nM); reduces diethanolamine-soluble Aβ40 levels in APP-YAC transgenic mouse brain from 1-10 mg/kg; reduces brain and cerebrospinal fluid Aβ40 levels in rats (ED50s = 6 and 10 mg/kg

MRK-560 – 1 mg

Brand:
Cayman
CAS:
677772-84-8
Storage:
-20
UN-No:
Non-Hazardous - /

MRK-560 is a potent inhibitor of γ-secretase (IC50 = 0.65 nM).{48318} In vivo, MRK-560 (1-10 mg/kg) reduces diethanolamine-soluble amyloid-β (1-40) (Aβ40) levels in APP-YAC transgenic mouse brain. MRK-560 reduces brain and cerebrospinal fluid Aβ40 levels in rats (ED50s = 6 and 10 mg/kg, respectively).{48319} It also decreases brain-soluble Aβ40 and Aβ42 levels and recovers hippocampal long-term potentiation in the Tg2576 transgenic mouse model of Alzheimer’s disease.{48320}  

 

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SKU: 27599 - 1 mg Category:

Description

A potent inhibitor of γ-secretase (IC50 = 0.65 nM); reduces diethanolamine-soluble Aβ40 levels in APP-YAC transgenic mouse brain from 1-10 mg/kg; reduces brain and cerebrospinal fluid Aβ40 levels in rats (ED50s = 6 and 10 mg/kg, respectively); decreases brain-soluble Aβ40 and Aβ42 levels and recovers hippocampal long-term potentiation in the Tg2576 transgenic mouse model of Alzheimer’s disease

Formal name: N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoro-methanesulfonamide

Synonyms: 

Molecular weight: 517.9

CAS: 677772-84-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis|Lysosomal Proteases||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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