A CAP with antibacterial activity; active against the Gram-negative bacteria E. coli

CAP 3 – 5 mg

Brand:
Cayman
CAS:
2292123-03-4
Storage:
-20
UN-No:
Non-Hazardous - /

CAP 3 is a cholic acid-peptide conjugate (CAP) with antibacterial activity.{35740} It is active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 μM, respectively). CAP 3 increases the fluidity of model Gram-negative bacterial membranes and binds to LPS in vitro. It reduces the biomass and number of colony-forming units in E. coli biofilms in a concentration-dependent manner. CAP 3 inhibits E. coli biofilm formation on catheters implanted in mice infected with E. coli at the incision site when applied as a coating on the catheters. CAP 3 (40 mg/kg) also reduces bacterial load in E. coli-infected wounds in mice. It is cytotoxic to A459 cells (IC50 = 56.4 μM) and has hemolytic activity against human red blood cells with a 50% lysis (HC50) value of 48 μM.  

 

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SKU: 27505 - 5 mg Category:

Description

A CAP with antibacterial activity; active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 μM, respectively); increases the fluidity of model Gram-negative bacterial membranes and binds to LPS in vitro; reduces the biomass and number of colony-forming units in E. coli biofilms; inhibits E. coli biofilm formation on catheters implanted in mice infected with E. coli at the incision site when applied as a coating on the catheters; reduces bacterial load in E. coli-infected wounds in mice at 40 mg/kg; cytotoxic to A459 cells (IC50 = 56.4 μM) and has hemolytic activity against human red blood cells (HC50 = 48 μM)

Formal name: (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-((R)-5-(benzyloxy)-5-oxopentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triyl tris(2-((S)-2-amino-3-methylbutanamido)acetate)

Synonyms: 

Molecular weight: 967.3

CAS: 2292123-03-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia

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