A fungal metabolite; cytotoxic to various human solid tumor cell lines

Globosuxanthone A – 5 mg

Brand:
Cayman
CAS:
917091-74-8
Storage:
-20
UN-No:
Non-Hazardous - /

Globosuxanthone A is a fungal metabolite originally isolated from C. globosum.{48211} It is cytotoxic to various human solid tumor cell lines, including MCF-7, PC3, LNCap, and DU145 cells (IC50s = 1.3, 0.65, 1.5, and 1.2 µM, respectively). It induces accumulation of cells in the G2/M and S phases of the cell cycle in NCI-H460 and PC3M cells. Globosuxanthone A is also active against C. albicans but not S. aureus, E. coli, or M. hiemalis.{48212}  

 

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Description

A fungal metabolite; cytotoxic to various human solid tumor cell lines, including MCF-7, PC3, LNCap, and DU145 cells (IC50s = 1.3, 0.65, 1.5, and 1.2 µM, respectively); active against C. albicans

Formal name: (1R,2R)-2,9-dihydro-1,2,8-trihydroxy-9-oxo-1H-xanthene-1-carboxylic acid, methyl ester

Synonyms: 

Molecular weight: 304.3

CAS: 917091-74-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Candidiasis

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