A fungal metabolite with diverse biological activities; inhibits binding of atractyloside to rat liver mitochondria in an ADP-dependent manner at 50 μM in a radioligand binding assay; reduces the glutathione content of rat liver mitochondria to 28% of controls at 20 μM; inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations; competes with MIP-1α for binding to CCR5 chemokine receptors in vitro (IC50 = 21 μM)

Fuscin – 5 mg

Brand:
Cayman
CAS:
83-85-2
Storage:
-20
UN-No:
Non-Hazardous - /

Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities.{46199,46200,46201} It inhibits binding of the ADP/ATP translocase inhibitor atractyloside (Item No. 14804) to rat liver mitochondria in an ADP-dependent manner when used at a concentration of 50 μM in a radioligand binding assay.{46199} Fuscin (20 μM) reduces the glutathione content of rat liver mitochondria to 28% of controls and inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations in a concentration-dependent manner.{46200} It competes with macrophage inflammatory protein 1α (MIP-1α) for binding to CCR5 chemokine receptors in vitro with an IC50 value of 21 μM.{46201}  

 

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SKU: 27485 - 5 mg Category:

Description

A fungal metabolite with diverse biological activities; inhibits binding of atractyloside to rat liver mitochondria in an ADP-dependent manner at 50 μM in a radioligand binding assay; reduces the glutathione content of rat liver mitochondria to 28% of controls at 20 μM; inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations; competes with MIP-1α for binding to CCR5 chemokine receptors in vitro (IC50 = 21 μM)

Formal name: 9,10-dihydro-5-hydroxy-4,8,8-trimethyl-2H,4H-benzo[1,2-b:4,3-c’]dipyran-2,6(8H)-dione

Synonyms: 

Molecular weight: 276.3

CAS: 83-85-2

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Ox Stress Reagents||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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