Description
A triterpene with diverse biological activities; induces nuclear translocation of the GR and reduces TNF-α-induced NF-κB signaling in HEK293 cells overexpressing GFP-GR; suppresses RANKL-induced NF-κB activation, ERK phosphorylation, and osteoclastogenesis in mouse BMMs at 12.5, 25, and 50 μM; induces neurite outgrowth in Neuro2A cells; decreases escape latency in the Morris water maze and increases the length of neurite processes in the hippocampus of aged mice at 10 mg/kg per day; topical administration reduces TPA-induced expression of COX-2, iNOS, TNF-α, and IL-1β and ear edema in a mouse model of dermatitis; recovers reductions in femoral bone mineral density and trabecular thickness and number in a rat model of ovariectomy-induced osteoporosis
Formal name: 3β,16α-dihydroxy-olean-12-en-28-oic acid
Synonyms:
Molecular weight: 472.7
CAS: 510-30-5
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory
