A lignan; an inhibitor of Δ5-desaturase (Ki = 0.28 mM); selective for Δ5-desaturase over Δ6- and Δ9-desaturase; cytotoxic to A2780 and SKOV3 ovarian cancer cells (IC50s = 38.45 and 60.87 µM

Asarinin – 1 mg

Brand:
Cayman
CAS:
133-04-0
Storage:
-20
UN-No:
Non-Hazardous - /

Asarinin is a lignan that has been found in A. sieboldii.{51057} It is an epimer of sesamin (Item No. 70310) and a noncompetitive inhibitor of Δ5-desaturase (Ki = 0.28 mM).{51058} It is selective for Δ5-desaturase over Δ6- and Δ9-desaturase. Asarinin is cytotoxic to A2780 and SKOV3 ovarian cancer cells (IC50s = 38.45 and 60.87 µM, respectively) but not immortalized ovarian surface epithelial cells (IC50 = >200 µM).{51057} It induces apoptosis and activates caspase-3, -8, and -9 in A2780 and SKOV3 cells.  

 

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SKU: 27456 - 1 mg Category:

Description

A lignan; an inhibitor of Δ5-desaturase (Ki = 0.28 mM); selective for Δ5-desaturase over Δ6- and Δ9-desaturase; cytotoxic to A2780 and SKOV3 ovarian cancer cells (IC50s = 38.45 and 60.87 µM, respectively) but not immortalized ovarian surface epithelial cells (IC50 = >200 µM)

Formal name: 5,5′-[(1R,3aS,4S,6aS)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis-1,3-benzodioxole

Synonyms:  (–)-Asarinin|(–)-Episesamin|Desgeranyloxyarmatumin|L-Asarinin

Molecular weight: 354.4

CAS: 133-04-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Lignans||Product Type|Biochemicals|Small Molecule Activators|Caspases||Product Type|Biochemicals|Small Molecule Inhibitors|Fatty Acid Metabolism||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Lipid Biochemistry|Fatty Acids

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