Description
An apigenin triglycoside with diverse biological activities; increases PTH release from rat primary parathyroid gland cells at 1 µM and inhibits calcium influx in HEK293 cells; increases serum PTH, as well as serum and bone calcium levels, in a streptozotocin-induced mouse model of diabetes with osteoporosis at 5 and 20 mg/kg three times per week; reduces increases in the expression and levels of CaSR in the kidney of diabetic osteoporotic mice; decreases infarct volume in a rat model of ischemic stroke at 10, 30, and 60 mg/kg and decreases the levels of the necroptosis-associated proteins RIPK3 and MLKL in the brain of ischemic rats at 30 mg/kg
Formal name: 7-[(O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→6)]-β-D-glucopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Synonyms:
Molecular weight: 724.7
CAS: 260413-62-5
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Glycosides||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Thyroid Hormones||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Neuroscience|Neuroprotection|Ischemia
