An inhibitor of KAT6A and KAT6B (IC50s = 8 and 28 nM

MOZ-IN-3 – 5 mg

Brand:
Cayman
CAS:
2055397-18-5
Storage:
-20
UN-No:
Non-Hazardous - /

MOZ-IN-3 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) and KAT6B/MORF (IC50s = 8 and 28 nM, respectively).{51034} It is selective for KAT6A and KAT6B over KAT5 and KAT7 (IC50s = 224 and 342 nM, respectively). MOZ-IN-3 induces cell cycle arrest in and inhibits proliferation of mouse embryonic fibroblasts (IC50 = 2.4 µM) and inhibits proliferation of EMRK1184 lymphoma cells (IC50 = 2.3 µM). It induces genetic and morphological changes associated with cellular senescence without inducing DNA damage, apoptosis, or necrosis. MOZ-IN-3 (10 µM) decreases global levels of acetylated histone H3 lysine 14 (H3K14Ac) by 49% and reduces H3K9Ac levels at the transcription start sites of Ezh2, Melk, and E2f2.  

 

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SKU: 27402 - 5 mg Category:

Description

An inhibitor of KAT6A and KAT6B (IC50s = 8 and 28 nM, respectively); selective for KAT6A and KAT6B over KAT5 and KAT7 (IC50s = 224 and 342 nM, respectively); induces cell cycle arrest in and inhibits proliferation of mouse embryonic fibroblasts (IC50 = 2.4 µM) and inhibits proliferation of EMRK1184 lymphoma cells (IC50 = 2.3 µM); induces genetic and morphological changes associated with cellular senescence; decreases global levels of H3K14Ac by 49% and reduces H3K9Ac levels at the transcription start sites of Ezh2, Melk, and E2f2

Formal name: 4-fluoro-5-methyl-[1,1′-biphenyl]-3-carboxylic acid, 2-(phenylsulfonyl)hydrazide

Synonyms:  WM-8014

Molecular weight: 384.4

CAS: 2055397-18-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acetyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Acetylation

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