A flavonoid; scavenges DPPH and ABTS radicals (EC50s = 0.52 and 0.48 mg/ml

Nicotiflorin – 5 mg

Brand:
Cayman
CAS:
17650-84-9
Storage:
-20
UN-No:
Non-Hazardous - /

Nicotiflorin is a flavonoid that has been found in I. glandulifera and has antioxidant and neuroprotective activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS (Item No. 27317) radicals with EC50 values of 0.52 and 0.48 mg/ml, respectively, in cell-free assays.{47729} Nicotiflorin (1 µM) prevents hydrogen peroxide-induced decreases in tyrosine hydroxylase activity in PC12 cells and cell death in primary rat mesencephalic neurons.{47730} It decreases infarct volume by 24.5, 45.8, and 63.2% when administered at doses of 2.5, 5, and 10 mg/kg, respectively, in a rat model of cerebral ischemia-reperfusion injury induced by transient middle central artery occlusion (MCAO).{47731}  

 

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SKU: 27392 - 5 mg Category:

Description

A flavonoid; scavenges DPPH and ABTS radicals (EC50s = 0.52 and 0.48 mg/ml, respectively) in cell-free assays; prevents hydrogen peroxide-induced decreases in tyrosine hydroxylase activity in PC12 cells and cell death in isolated rat mesencephalic neurons at 1 µM; decreases infarct size by 24.5, 45.8, and 63.2% at 2.5, 5, and 10 mg/kg, respectively, in a rat model of cerebral ischemia-reperfusion injury induced by transient MCAO

Formal name: 3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Synonyms:  3,4′,5,7-Tetrahydroxyflavone 3-rhamnoglucoside|Kaempferol 3-O-β-rutinoside

Molecular weight: 594.5

CAS: 17650-84-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Neuroscience|Neuroprotection|Ischemia||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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