A 15-LO-1 inhibitor (IC50 = 32 nM); selective for 15-LO-1 over 15-LO-2

BLX3887 – 1 mg

Brand:
Cayman
CAS:
934758-70-0
Storage:
-20
UN-No:
Non-Hazardous - /

BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1; IC50 = 32 nM in a cell-free enzyme assay).{35444} It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 nM). BLX3887 inhibits the production of 15-LO metabolites selectively in eosinophils over neutrophils when used at a concentration of 10 µM. It also inhibits endocytosis in, and the migration of, isolated human peripheral blood mononuclear cell-derived dendritic cells in vitro.  

 

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SKU: 27391 - 1 mg Category:

Description

A 15-LO-1 inhibitor (IC50 = 32 nM); selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM) and 12-LO (IC50 = 3,310 nM); inhibits endocytosis in, and the migration of, isolated human peripheral blood mononuclear cell-derived dendritic cells in vitro

Formal name: 4,5-dichloro-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide

Synonyms:  15-LO-1 Inhibitor 3887

Molecular weight: 308.5

CAS: 934758-70-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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