An aldohexose monosaccharide; an epimer of glucose; decreases T cell proliferation and increases FoxP3+ T regulatory cells in vitro; prevents diabetes in NOD mice at 1.1 M in the drinking water; rescues the nonviable phenotype and deficits in glycosylation in Pmm2R137H/F118L mice at 9 mg/ml in the drinking water; serum levels of mannose are reduced in patients with PMM2-CDG

D-Mannose – 100 g

Brand:
Cayman
CAS:
3458-28-4
Storage:
-20
UN-No:
Non-Hazardous - /

D-Mannose is an aldohexose monosaccharide and an epimer of glucose. D-Mannose is found in animals, microbes, and plants, can be used as an energy source by conversion to glucose, and can also be produced from glucose.{30551} It is converted via hexokinase to mannose-6-phosphate and then to intermediates that are incorporated into proteins via N-linked glycosylation. It decreases T cell proliferation and increases FoxP3+ T regulatory cells in vitro and prevents diabetes in non-obese diabetic (NOD) mice, a model of autoimmune diabetes, when administered at a dose of 1.1 M in the drinking water.{43946} D-Mannose administration during gestation at a dose of 9 mg/ml in the drinking water rescues the embryonic lethal phenotype and prevents deficits in glycosylation in Pmm2R137H/F118L mice, a transgenic model of the congenital glycosylation disorder (CDG) PMM2-CDG, which is characterized by phosphomannomutase 2 (PMM2) gene mutations.{43947} Levels of D-mannose are reduced in the serum of patients with PMM2-CDG.{43948} Formulations containing D-mannose have been used in the treatment of mannose phosphate isomerase CDG (MPI-CDG).  

 

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SKU: 27388 - 100 g Category:

Description

An aldohexose monosaccharide; an epimer of glucose; decreases T cell proliferation and increases FoxP3+ T regulatory cells in vitro; prevents diabetes in NOD mice at 1.1 M in the drinking water; rescues the nonviable phenotype and deficits in glycosylation in Pmm2R137H/F118L mice at 9 mg/ml in the drinking water; serum levels of mannose are reduced in patients with PMM2-CDG

Formal name:

Synonyms:  (+)-Mannose|Carubinose|NSC 26247

Molecular weight: 180.2

CAS: 3458-28-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Carbohydrates||Product Type|Biochemicals|Natural Products||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Autoimmunity

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