Description
An inhibitor of STK16 (IC50 = 295 nM); selective for STK16 over mTOR, PI3Kδ, and PI3Kγ (IC50s = 5,560, 856, and 867 nM, respectively, in an enzyme assay) and over 440 additional kinases in a KinomeScan profiling assay; decreases the growth of MCF-7 cells (GI50 = ~10 µM); potentiates the antiproliferative effects of colchicine, paclitaxel, doxorubicin, and cisplatin in MCF-7 cells at 2.5-5 µM
Formal name: 1-(4-fluoro-3-methylphenyl)-1,7-dihydro-2H-pyrrolo[2,3-h]-1,6-naphthyridin-2-one
Synonyms:
Molecular weight: 293.3
CAS: 1223001-53-3
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Research Area|Cancer|Cell Signaling
