Description
A partial agonist of LXRα and LXRβ (Kis = 68 and 14 nM, respectively, in a radioligand binding assay); activates LXRα and LXRβ with EC50 values of 230 and 250 nM, respectively, in a transactivation assay increases expression of ABCA1 in HeLa cells and isolated human and mouse whole blood (EC50s = 33, 1,200, and 120 nM, respectively); increases expression of Abca1 and Abcg2 in mouse blood cells but does not increase plasma or hepatic triglycerides at 10 mg/kg
Formal name: 2-[1-(2-chlorophenyl)-1-methylethyl]-α,α-dimethyl-1-[3′-(methylsulfonyl)[1,1′-biphenyl]-4-yl]-1H-imidazole-4-methanol
Synonyms:
Molecular weight: 509.1
CAS: 918348-67-1
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|FXRs & LXRs
