Description
A multi-kinase inhibitor; inhibits 35 kinases (IC50s = 0.5-4,098 nM) in a panel of 55 RTKs; reduces proliferation in various cancer cells (IC50s = 340.1-1,830 nM) and decreases phosphorylation of IGF1-R, PDGFRβ, and Akt at 62.5-4,000 nM; decreases tumor growth in LPS141 and MPNST mouse xenograft models at 15 mg/kg per day
Formal name: N-[3-fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N’-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
Synonyms: MGCD-516
Molecular weight: 629.7
CAS: 1123837-84-2
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling
