An ATP-competitive inhibitor of VPS34 (IC50 = 19 nM); inhibits autophagy induced by rapamycin or amino acid starvation (IC50s = 40 and 90 nM

Autophinib – 10 mg

Brand:
Cayman
CAS:
1644443-47-9
Storage:
-20
UN-No:
Non-Hazardous - /

Autophinib is an ATP-competitive inhibitor of the PI3K VPS34 (IC50 = 19 nM).{49061} It inhibits autophagy induced by the mTOR inhibitor rapamycin (Item No. 13346) or by amino acid starvation (IC50s = 40 and 90 nM, respectively) in MCF-7 cells. Autophinib also induces apoptosis in amino acid-starved MCF-7 cells with an EC50 value of 234 nM.  

 

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SKU: 27320 - 10 mg Category:

Description

An ATP-competitive inhibitor of VPS34 (IC50 = 19 nM); inhibits autophagy induced by rapamycin or amino acid starvation (IC50s = 40 and 90 nM, respectively) in MCF-7 cells; induces apoptosis in amino acid-starved MCF-7 cells (EC50 = 234 nM)

Formal name: 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-4-pyrimidinamine

Synonyms: 

Molecular weight: 346.7

CAS: 1644443-47-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy

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