A steroid glycoside and saponin with diverse biological activities; inhibits PMA-induced expression of MMP-1

Ginsenoside Rh1 – 25 mg

Brand:
Cayman
CAS:
63223-86-9
Storage:
-20
UN-No:
Non-Hazardous - /

Ginsenoside Rh1 is a steroid glycoside and saponin that has been found in red ginseng and has diverse biological activities.{47437,47438} It inhibits expression of matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-9 induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in U87MG and U373MG human astroglioma cells in a concentration-dependent manner.{47438} Ginsenoside Rh1 (300 μM) also inhibits PMA-induced invasion and migration of these cell lines in Matrigel™ invasion and wound healing assays, respectively. It inhibits LPS-induced increases in nitrite accumulation, prostaglandin E2 (PGE2; Item No. 14010) synthesis, and inducible nitric oxide synthase (iNOS) protein levels in RAW 264.7 cells and inhibits histamine release induced by compound 48/80 (Item No. 22173) in rat peritoneal mast cells (IC50 = 37 μM).{47439} Ginsenoside Rh1 (25 mg/kg, i.p.) inhibits IgE-induced passive cutaneous anaphylaxis reactions in mice by 87%. Ginsenoside Rh1 is also a metabolite of ginsenoside Re (Item No. 15330) and ginsenoside Rg1 (Item No. 15315) formed by intestinal microflora.{47438,25016}  

 

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SKU: 27318 - 25 mg Category:

Description

A steroid glycoside and saponin with diverse biological activities; inhibits PMA-induced expression of MMP-1, MMP-3, and MMP-9 in U87MG and U373MG human astroglioma cells; inhibits PMA-induced invasion and migration of astroglioma cells in Matrigel™ invasion and wound healing assays, respectively, at 300 μM; inhibits LPS-induced increases in nitrite accumulation, PGE2 synthesis, and iNOS protein levels in RAW 264.7 cells; inhibits histamine release induced by compound 48/80 in rat peritoneal mast cells (IC50 = 37 μM); inhibits IgE-induced passive cutaneous anaphylaxis reactions in mice by 87% at 25 mg/kg, i.p.; a metabolite of ginsenoside Re and ginsenoside Rg1 formed by intestinal microflora

Formal name: (3β,6α,12β)-3,12,20-trihydroxydammar-24-en-6-yl, β-D-glucopyranoside

Synonyms:  20(S)-Ginsenoside Rh1|Prosapogenin A2|Sanchinoside Rh1

Molecular weight: 638.9

CAS: 63223-86-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Natural Products|Ginsenosides||Product Type|Biochemicals|Natural Products|Glycosides||Product Type|Biochemicals|Natural Products|Saponins||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity

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