An alkaloid with diverse biological activities; active against P. falciparum (IC50s = 422 and 1

Jatrorrhizine (chloride) – 1 mg

Brand:
Cayman
CAS:
6681-15-8
Storage:
-20
UN-No:
Non-Hazardous - /

Jatrorrhizine is an alkaloid that has been found in the Chinese herb C. chinensis and has diverse biological activities.{45262,45263,45264,45265} It is active against P. falciparum (IC50s = 422 and 1,607 ng/ml for D-6 and W-2 clones, respectively) and E. histolytica (IC50 = 82.7 μM).{45262,45263} Jatrorrhizine inhibits the growth of C8161 human melanoma cells in vitro (IC50 = 47.4 μM) and inhibits C8161 cell-mediated neovascularization in a Matrigel™ plug assay in mice when administered at a dose of 50 μg/animal.{45264} It reduces serum levels of triglycerides, LDL cholesterol (LDL-C), aspartate transaminase (AST), and alanine aminotransferase (ALT) in a high-fat diet-induced mouse model of hyperlipidemia when administered at doses of 20 and 100 mg/kg.{45265} Jatrorrhizine is also a metabolite of berberine (Item No. 10006427).{45266}  

 

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Description

An alkaloid with diverse biological activities; active against P. falciparum (IC50s = 422 and 1,607 ng/ml for D-6 and W-2 clones, respectively) and E. histolytica (IC50 = 82.7 μM); inhibits the growth of C8161 human melanoma cells in vitro (IC50 = 47.4 μM); inhibits C8161 cell-mediated neovascularization in a Matrigel™ plug assay in mice at 50 μg/animal; reduces serum levels of triglycerides, LDL-C, AST, and ALT in a high-fat diet-induced mouse model of hyperlipidemia at 20 and 100 mg/kg; a metabolite of berberine

Formal name: 5,6-dihydro-3-hydroxy-2,9,10-trimethoxy-dibenzo[a,g]quinolizinium, monochloride

Synonyms:  NSC 645313

Molecular weight: 373.8

CAS: 6681-15-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiamoebics||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cancer|Angiogenesis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Parasitic Diseases|Malaria

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