An antagonist of L3MBTL1

UNC926 – 5 mg

Brand:
Cayman
CAS:
1184136-10-4
Storage:
-20
UN-No:
Non-Hazardous - /

UNC926 is an antagonist of the MBT domain-containing methyl-lysine reader proteins L3MBTL1, L3MBTL3, and L3MBTL4.{48422} It inhibits methyl-lysine histone peptide substrate binding of L3MBTL1, L3MBTL3, and L3MBTL4 (IC50s =3.9, 3.2, and 15.6 μM, respectively) selectively over MBT domain-containing MBTD1 and SFMBT1 and chromo domain-containing CBX7 (IC50s = >30 μM).  

 

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SKU: 27302 - 5 mg Category:

Description

An antagonist of L3MBTL1, L3MBTL3, and L3MBTL4; inhibits methyl-lysine histone peptide substrate binding of L3MBTL1, L3MBTL3, and L3MBTL4 (IC50s =3.9, 3.2, and 15.6 μM, respectively) selectively over MBTD1, SFMBT1, and CBX7 (IC50s = >30 μM)

Formal name: (3-bromophenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]-methanone

Synonyms: 

Molecular weight: 337.3

CAS: 1184136-10-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Chromatin Reader Interactions||Research Area|Epigenetics, Transcription, & Translation|Readers|MBT Domains

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