An inhibitor of autotaxin (IC50 = 170 nM); selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM; inhibits autotaxin-mediated production of LPA from LPC in vitro from 0.1-1

BMP-22 – 10 mg

Brand:
Cayman
CAS:
1306684-90-1
Storage:
-20
UN-No:
Non-Hazardous - /

BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM).{35710} It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC; Item No. 24331) in vitro in a concentration-dependent manner. It inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 (0.5 mg/kg per day) decreases the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis.  

 

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SKU: 27264 - 10 mg Category:

Description

An inhibitor of autotaxin (IC50 = 170 nM); selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM; inhibits autotaxin-mediated production of LPA from LPC in vitro from 0.1-1,000 nM; inhibits LPC-dependent MM1 cell invasion of a HUVEC monolayer; decreases the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis at 0.5 mg/kg per day

Formal name: p-[(4-pentadecylphenyl)methyl]-phosphonic acid

Synonyms: 

Molecular weight: 382.5

CAS: 1306684-90-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cancer|Cell Migration & Metastasis

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