Description
A synthetic GH secretagogue and an agonist of GHS-R; inhibits binding of the GHS-R agonist MK-0677/ibutamoren (Ki = 1.9 nM) and ghrelin (Kd = 260 nM) to GSH-R type Ia and GSH-R, respectively; stimulates intracellular calcium mobilization (EC50 = 4.5 nM) and inositol phosphate production (EC50 = 0.83 nM) in cells expressing the human receptor; negative allosteric modulator of ghrelin signaling; induces release of GH, but not TSH, LH, or FSH, in isolated rat pituitary gland at 0.03 μg/ml; increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood at 50 μg; increases food intake in rats at 0.3, 1, and 3 nmol
Formal name: L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide, triacetate
Synonyms: Hexapeptide-2|Growth Hormone Releasing Peptide 6|HWAWFK-NH2|SKF 110679|U 75799E
Molecular weight: 1,053.20
CAS: 145177-42-0
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Neuroscience|Behavioral Neuroscience|Food Intake||Research Area|Neuroscience|Neuroendocrinology
