An alkaloid with diverse biological activities; decreases synoviocyte proliferation and reduces paw and joint swelling in a rat model of adjuvant-induced arthritis when applied topically; reduces tumor incidence

Brucine – 100 g

Brand:
Cayman
CAS:
357-57-3
Storage:
-20
UN-No:
Dangerous Good - 1570 / 6.1

Brucine is an alkaloid that has been found in the seeds of the S. nux-vomica tree and has diverse biological activities, including anti-inflammatory, anticancer, and antioxidant properties.{47322} It inhibits prostaglandin E2 (PGE2; Item No. 14010) production induced by LPS in vitro.{47323} Topical administration of brucine decreases synoviocyte proliferation and reduces paw and joint swelling in a rat model of adjuvant-induced arthritis and decreases swelling in a mouse model of xylene-induced ear edema. Brucine (4 and 8 mg/kg per day) reduces tumor incidence, number, and volume in a rat model of mammary gland tumorigenesis induced by 7,12-dimethylbenz(a)anthracene (DMBA).{47322} It prevents decreases in superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activity and increases the level of glutathione (GSH) in mammary tissues, as well as reduces markers of lipid peroxidation in plasma and mammary tissue. Brucine also allosterically enhances the effect of low, but not high, concentrations of acetylcholine at M1 muscarinic acetylcholine receptors.{47324}  

 

Available on backorder

Add to quotes
SKU: 27221 - 100 g Category:

Description

An alkaloid with diverse biological activities; decreases synoviocyte proliferation and reduces paw and joint swelling in a rat model of adjuvant-induced arthritis when applied topically; reduces tumor incidence, number, and volume in a rat model of DMBA-induced mammary gland tumorigenesis at 4 and 8 mg/kg per day; prevents decreases in SOD, CAT, and GPX activity and increases the level of GSH in mammary tissues in a rat model of DMBA-induced mammary gland tumorigenesis at 4 and 8 mg/kg per day; allosterically enhances the effect of low, but not high, concentrations of acetylcholine at M1 muscarinic acetylcholine receptors

Formal name: 2,3-dimethoxy-strychnidin-10-one

Synonyms:  2,3-Dimethoxystrychnine

Molecular weight: 394.5

CAS: 357-57-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Cancer||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Catalase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

Related products

  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 50 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 50 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 500 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 500 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 5 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 5 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 1 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 1 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page