An alkaloid with diverse biological activities; decreases synoviocyte proliferation and reduces paw and joint swelling in a rat model of adjuvant-induced arthritis when applied topically; reduces tumor incidence

Brucine – 10 g

Brand:
Cayman
CAS:
357-57-3
Storage:
-20
UN-No:
Dangerous Good - 1570 / 6.1

Brucine is an alkaloid that has been found in the seeds of the S. nux-vomica tree and has diverse biological activities, including anti-inflammatory, anticancer, and antioxidant properties.{47322} It inhibits prostaglandin E2 (PGE2; Item No. 14010) production induced by LPS in vitro.{47323} Topical administration of brucine decreases synoviocyte proliferation and reduces paw and joint swelling in a rat model of adjuvant-induced arthritis and decreases swelling in a mouse model of xylene-induced ear edema. Brucine (4 and 8 mg/kg per day) reduces tumor incidence, number, and volume in a rat model of mammary gland tumorigenesis induced by 7,12-dimethylbenz(a)anthracene (DMBA).{47322} It prevents decreases in superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activity and increases the level of glutathione (GSH) in mammary tissues, as well as reduces markers of lipid peroxidation in plasma and mammary tissue. Brucine also allosterically enhances the effect of low, but not high, concentrations of acetylcholine at M1 muscarinic acetylcholine receptors.{47324}  

 

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SKU: 27221 - 10 g Category:

Description

An alkaloid with diverse biological activities; decreases synoviocyte proliferation and reduces paw and joint swelling in a rat model of adjuvant-induced arthritis when applied topically; reduces tumor incidence, number, and volume in a rat model of DMBA-induced mammary gland tumorigenesis at 4 and 8 mg/kg per day; prevents decreases in SOD, CAT, and GPX activity and increases the level of GSH in mammary tissues in a rat model of DMBA-induced mammary gland tumorigenesis at 4 and 8 mg/kg per day; allosterically enhances the effect of low, but not high, concentrations of acetylcholine at M1 muscarinic acetylcholine receptors

Formal name: 2,3-dimethoxy-strychnidin-10-one

Synonyms:  2,3-Dimethoxystrychnine

Molecular weight: 394.5

CAS: 357-57-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Cancer||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Catalase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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