Troxerutin – 5 g

Brand:
Cayman
CAS:
7085-55-4
Storage:
-20
UN-No:
Non-Hazardous - /

Troxerutin is a flavonoid that has been found in a variety of fruits and vegetables and has diverse biological activities.{48639,48640,48641} It reduces D-galactose-induced increases in renal malondialdehyde (MDA) levels and decreases in renal Cu/Zn superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX) activities in mice when administered at a dose of 150 mg/kg per day, as well as attenuates D-galactose-induced increases in renal levels of NF-κB p65, inducible nitric oxide synthase (iNOS), COX-2, and prostaglandin E2 receptor 2 (EP2).{48639} Troxerutin (150 mg/kg per day) reduces blood glucose levels, plasma triglyceride levels, heart rate, and blood pressure in a rat model of type 2 diabetes induced by streptozotocin (STZ; Item No. 13104).{48640} Troxerutin (150 mg/kg per day) prevents the loss of dopaminergic neurons in the substantia nigra pars compacta (SNC) and reduces apomorphine-induced contralateral rotations in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{48641}  

 

Available on backorder

SKU: 27220 - 5 g Category:

Description

A flavonoid with diverse biological activities; reduces D-galactose-induced increases in renal MDA levels and decreases in renal Cu/Zn SOD, catalase, and GPX activities in mice at 150 mg/kg per day, as well as attenuates D-galactose-induced increases in renal levels of NF-κB p65, iNOS, COX-2, and EP2 levels; reduces blood glucose levels, plasma triglyceride levels, heart rate, and blood pressure in a rat model of STZ-induced type 2 diabetes at 150 mg/kg per day; prevents the loss of dopaminergic neurons in the SNC and reduces apomorphine-induced contralateral rotations in a rat model of Parkinson’s disease induced by 6-OHDA at 150 mg/kg per day


Formal name: 2-[3,4-bis(2-hydroxyethoxy)phenyl]-3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-4H-1-benzopyran-4-one

Synonyms:  Trihydroxyethylrutin|Vitamin P4

Molecular weight: 742.7

CAS: 7085-55-4

Purity: ≥90%

Formulation: A crystalline solid


Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Cardiovascular System|Lipids & Lipoproteins||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Neuroscience|Neuroprotection||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Catalase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase