A reversible Kif18A inhibitor (IC50 = 1.69 μM); selective for Kif18A over a panel of seven kinesins at 100 μM; inhibits Kif18A-dependent microtubule motility in a microtubule gliding assay at 100 μM; induces mitotic accumulation of HeLa cells

BTB-1 – 500 mg

Brand:
Cayman
CAS:
86030-08-2
Storage:
-20
UN-No:
Non-Hazardous - /

BTB-1 is a reversible inhibitor of the kinesin-8 family motor protein Kif18A (IC50 = 1.69 μM).{46312} It is selective for Kif18A over a panel of seven kinesins at 100 μM. BTB-1 (100 μM) inhibits Kif18A-dependent microtubule motility in a microtubule gliding assay. It induces mitotic accumulation of HeLa cells in a dose-dependent manner.  

 

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SKU: 27219 - 500 mg Category:

Description

A reversible Kif18A inhibitor (IC50 = 1.69 μM); selective for Kif18A over a panel of seven kinesins at 100 μM; inhibits Kif18A-dependent microtubule motility in a microtubule gliding assay at 100 μM; induces mitotic accumulation of HeLa cells

Formal name: 4-chloro-2-nitro-1-(phenylsulfonyl)-benzene

Synonyms:  NSC 156750|NSC 658180

Molecular weight: 297.7

CAS: 86030-08-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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