A mixture of LacCers isolated from bovine buttermilk with variable N-acyl chain lengths; expressed on the plasma membrane of human phagocytes; mediates phagocytosis

Lactosylceramides (bovine buttermilk) – 1 mg

Brand:
Cayman
CAS:
4682-48-8
Storage:
-20
UN-No:
Non-Hazardous - /

Lactosylceramide (LacCer) is an endogenous bioactive sphingolipid. It is expressed on the plasma membrane of human phagocytes and mediates phagocytosis, chemotaxis, and superoxide generation.{41044} LacCer forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors, suggesting a role in cell signaling. Elevated LacCer levels in kidney cortex homogenates and urine are directly correlated with hyperglycemia, insulin resistance, and obesity in db/db transgenic diabetic mice.{41045} It promotes recruitment of CNS-infiltrating monocytes and microglia and enhances neurodegeneration in mice with chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS).{27728} Increased levels of LacCer in atherosclerotic plaques are correlated with increased levels of the pro-inflammatory cytokines IL-6, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein 1β (MIP-1β), as well as lipids and macrophages.{41046} LacCer is also upregulated during the secretory phase of the menstrual cycle.{41047} This product is a mixture of LacCers isolated from bovine buttermilk with variable N-acyl chain lengths. [Matreya, LLC. Catalog No. 1507]  

 

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SKU: 27197 - 1 mg Category:

Description

A mixture of LacCers isolated from bovine buttermilk with variable N-acyl chain lengths; expressed on the plasma membrane of human phagocytes; mediates phagocytosis, chemotaxis, and superoxide generation; forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors; elevated levels in kidney cortex homogenates and urine are directly correlated with hyperglycemia, insulin resistance, and obesity in db/db transgenic diabetic mice; promotes recruitment of CNS-infiltrating monocytes and microglia, and enhances neurodegeneration in mice with chronic EAE, a model of MS; correlated with increased levels of pro-inflammatory cytokines IL-6, MCP-1, and MIP-1β, as well as lipids and macrophages in atherosclerotic plaques

Formal name: 1-O-(4-O-β-D-galactopyranosyl-β-D-glucopyranosyl)-ceramide

Synonyms:  LacCer

Molecular weight: 960.4

CAS: 4682-48-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience|Neurodegenerative Disorders

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