A fluorogenic substrate for caspase-8 and granzyme B; AFC is released upon enzymatic cleavage by caspase-8 or granzyme B and its fluorescence can be used to quantify caspase-8 or granzyme B activity; ex/em = 380/500 nm

Z-IETD-AFC – 1 mg

Brand:
Cayman
CAS:
219138-02-0
Storage:
-20
UN-No:
Non-Hazardous - /

Z-IETD-AFC is a fluorogenic substrate for caspase-8 and granzyme B.{48146} Upon enzymatic cleavage by caspase-8 or granzyme B, 7-amino-4-trifluoromethylcoumarin (AFC) is released and its fluorescence can be used to quantify caspase-8 or granzyme B activity. AFC displays excitation/emission maxima of 380/500 nm, respectively.  

 

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SKU: 27101 - 1 mg Category:

Description

A fluorogenic substrate for caspase-8 and granzyme B; AFC is released upon enzymatic cleavage by caspase-8 or granzyme B and its fluorescence can be used to quantify caspase-8 or granzyme B activity; ex/em = 380/500 nm, respectively

Formal name: N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-L-threonyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine

Synonyms:  Z-Ile-Glu-Thr-Asp-7-amino-4-Trifluormethylcoumarin

Molecular weight: 821.8

CAS: 219138-02-0

Purity: ≥90%

Formulation: A solid

Application|Enzyme Activity||Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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