A ferroptosis inducer and inhibitor of the system xc- cystine/glutamate transporter; inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 µM); induces cell death in HAP1 cells at 5 µM

Erastin2 – 5 mg

Brand:
Cayman
CAS:
1695533-44-8
Storage:
-20
UN-No:
Non-Hazardous - /

Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.{35682,43340} It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 µM).{43340} It induces cell death in HAP1 cells when used at a concentration of 5 µM, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 (Item No. 17729) or deferoxamine (Item No. 14595).{35682} Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 µM), an effect that can be blocked by the reducing agent β-mercaptoethanol (EC50 = >20 µM).{35628} It increases lipid peroxidation in HT-1080 cells when used at a concentration of 1 µM.  

 

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SKU: 27087 - 5 mg Category:

Description

A ferroptosis inducer and inhibitor of the system xc- cystine/glutamate transporter; inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 µM); induces cell death in HAP1 cells at 5 µM, an effect that can be blocked by ferrostatin-1 or deferoxamine; induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 µM); increases lipid peroxidation in HT-1080 cells at 1 µM

Formal name: 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1′-biphenyl]-3-yl]-4(3H)-quinazolinone

Synonyms: 

Molecular weight: 623.1

CAS: 1695533-44-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Cell Death|Ferroptosis||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity

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