Description
A ferroptosis inducer and inhibitor of the system xc- cystine/glutamate transporter; inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 µM); induces cell death in HAP1 cells at 5 µM, an effect that can be blocked by ferrostatin-1 or deferoxamine; induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 µM); increases lipid peroxidation in HT-1080 cells at 1 µM
Formal name: 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1′-biphenyl]-3-yl]-4(3H)-quinazolinone
Synonyms:
Molecular weight: 623.1
CAS: 1695533-44-8
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Cell Death|Ferroptosis||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity
