A biosynthetic precursor to steroids; an oil-in-water emulsion synergistically increases adaptive immune responses to GLA compared with an aqueous formulation of GLA

Squalene – 100 g

Brand:
Cayman
CAS:
111-02-4
Storage:
-20
UN-No:
Non-Hazardous - /

Squalene is a biosynthetic precursor to all steroids and a terpene originally isolated from shark liver oil.{45222,45221} Squalene is produced in mammals by condensation of two farnesyl diphosphate molecules by squalene synthase and then oxidized to squalene epoxide for use in the biosynthesis of lanosterol (Item No. 19521), cholesterol, and other steroids.{45222} An oil-in-water emulsion of squalene synergistically increases adaptive immune responses to glucopyranosyl lipid adjuvant (GLA), a toll-like receptor 4 (TLR4) agonist, compared with an aqueous formulation of GLA.{45223} Formulations containing squalene have been used as adjuvants in vaccines and as hair and skin conditioning agents.  

 

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SKU: 27058 - 100 g Category:

Description

A biosynthetic precursor to steroids; an oil-in-water emulsion synergistically increases adaptive immune responses to GLA compared with an aqueous formulation of GLA

Formal name: (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene

Synonyms:  trans-Squalene|Spinacene

Molecular weight: 410.7

CAS: 111-02-4

Purity: ≥95%

Formulation: A neat oil

Product Type|Biochemicals|Lipids|Hydrocarbons||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Lipid Biochemistry

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