A pan-Trk inhibitor (IC50s = 2-20 nM for TrkA

LOXO-101 – 1 mg

Brand:
Cayman
CAS:
1223403-58-4
Storage:
-20
UN-No:
Non-Hazardous - /

LOXO-101 is an inhibitor of the tropomyosin-related kinases TrkA, TrkB, and TrkC (IC50s = 2-20 nM).{42680} It is selective for TrkA, -B, and -C over a panel of 226 kinases at 1 μM. LOXO-101 inhibits the growth of CUTO-3.29, KM12, and MO-91 patient-derived cancer cell lines (IC50s = In vivo, LOXO-101 (60 and 200 mg/kg) reduces tumor growth in a KM12 mouse xenograft model.  

 

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SKU: 27056 - 1 mg Category:

Description

A pan-Trk inhibitor (IC50s = 2-20 nM for TrkA, TrkB, and TrkC); selective for TrkA, -B, and -C over a panel of 226 kinases at 1 μM; inhibits the growth of CUTO-3.29, KM12, and MO-91 patient-derived cancer cell lines (IC50s = <100, <10, and <10 nM, respectively); reduces tumor growth in a KM12 mouse xenograft model at 60 and 200 mg/kg ,

Formal name: (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide

Synonyms:  ARRY-470|Larotrectinib

Molecular weight: 428.4

CAS: 1223403-58-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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