Description
A piperidine nitroxide and spin label with SOD mimetic activity; inhibits lipid peroxidation in rat liver microsomes (IP50s = 117, 61, and 381 μM for peroxidation induced by iron plus NADPH, iron plus ascorbate, and t-butylhydroperoxide, respectively); inhibits production of superoxide anions by 92% via a xanthine-xanthine oxidase reaction in vitro at 1 mM; reduces mean arterial pressure and heart rate in spontaneously hypertensive rats (ED50s = 70 and 63 μmol/kg, respectively) when administered intravenously; a cell-permeable spin label that has been used to quantify intracellular oxygen in various cell types by ESR
Formal name: 4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy
Synonyms: 4-hydroxy TEMPO
Molecular weight: 172.2
CAS: 2226-96-2
Purity: ≥95%
Formulation: A crystalline solid
Application|EPR/ESR||Product Type|Biochemicals|Labeling & Detection|Reactive Probes||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Ox Stress Reagents|Spin Traps||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen
