A multi-kinase inhibitor (IC50s = 0.3

XL647 – 10 mg

Brand:
Cayman
CAS:
781613-23-8
Storage:
-20
UN-No:
Non-Hazardous - /

XL647 is a multi-kinase inhibitor (IC50s = 0.3, 16, 1.5, 8.7, and 1.4 nM for EGFR, ErbB2, KDR, FLT4, and EphB4, respectively).{45304} It is selective for these kinases over a panel of 10 tyrosine kinases and 55 serine/threonine kinases at 10 μM. XL647 inhibits growth of A431 cells expressing wild-type EGFR and H1975 non-small cell lung cancer (NSCLC) cells expressing both the activating mutant EGFRL858R and the drug resistance-associated mutant EGFRT790M (IC50s = 13 and 920 nM, respectively). In vivo, XL647 (10, 30, and 100 mg/kg) inhibits tumor growth and EGFR phosphorylation in an H1975 mouse xenograft model in a dose-dependent manner.  

 

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SKU: 27049 - 10 mg Category:

Description

A multi-kinase inhibitor (IC50s = 0.3, 16, 1.5, 8.7, and 1.4 nM for EGFR, ErbB2, KDR, FLT4, and EphB4, respectively); selective for these kinases over a panel of 10 tyrosine kinases and 55 serine/threonine kinases at 10 μM; inhibits growth of A431 cells expressing wild-type EGFR and H1975 NSCLC cells expressing both EGFRL858R and EGFRT790M (IC50s = 13 and 920 nM, respectively); inhibits tumor growth and EGFR phosphorylation in an H1975 mouse xenograft model at 10, 30, and 100 mg/kg

Formal name: N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aα,5β,6aα)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]-4-quinazolinamine

Synonyms:  EXEL-7647|Tesevatinib

Molecular weight: 491.4

CAS: 781613-23-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cancer|Multidrug Resistance

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