An inhibitor of TLR2 signaling; inhibits synthetic and bacterial TLR2 agonist-induced TLR2/1 and TLR2/6 signaling in HEK-TLR2 cells at 50 µM; decreases the PAM3CSK4-induced expression of IL-8 in HEK-TLR2 cells; inhibits the Pam3CSK4-induced TLR2-MyD88 interaction

C29 – 10 mg

Brand:
Cayman
CAS:
363600-92-4
Storage:
-20
UN-No:
Non-Hazardous - /

C29 is an inhibitor of toll-like receptor 2 (TLR2) signaling.{46288} It inhibits synthetic and bacterial TLR2 agonist-induced TLR2/1 and TLR2/6 signaling in HEK-293T cells expressing human TLR2 (HEK-TLR2) and THP-1 cells when used at a concentration of 50 µM. C29 also inhibits TLR2/1 signaling in primary murine macrophages without inducing cytotoxicity. It decreases the expression of IL-8 induced by the synthetic bacterial lipopeptide TLR2 agonist Pam3CSK4 (Item No. 24126) in HEK-TLR2 cells. C29 (150 µM) inhibits the Pam3CSK4-induced interaction between TLR2 and the adapter protein MyD88, blocks MAPK activation, and decreases NF-κB activation and IκBα degradation in THP-1 cells.  

 

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SKU: 27029 - 10 mg Category:

Description

An inhibitor of TLR2 signaling; inhibits synthetic and bacterial TLR2 agonist-induced TLR2/1 and TLR2/6 signaling in HEK-TLR2 cells at 50 µM; decreases the PAM3CSK4-induced expression of IL-8 in HEK-TLR2 cells; inhibits the Pam3CSK4-induced TLR2-MyD88 interaction, blocks MAPK activation, and decreases NF-κB activation and IκBα degradation in THP-1 cells

Formal name: 3-[[(2-hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-benzoic acid

Synonyms:  TLR2-IN-C29

Molecular weight: 285.3

CAS: 363600-92-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases

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