An agonist of S. hermonthica ShHTL7; binds to ShHTL7 (IC50 = 0.31 µM) over ShHTL2-6

Sphynolactone-7 – 10 mg

Brand:
Cayman
CAS:
2305752-57-0
Storage:
-20
UN-No:
Non-Hazardous - /

Sphynolactone-7 (SPL7) is an agonist of Striga hyposensitive to light receptor 7 (ShHTL7), which is found in the parasitic plant S. hermonthica.{35472} It selectively binds to ShHTL7 (IC50 = 0.31 µM) over ShHTL2-6, ShHTL9-10, and the strigolactone receptor AtD14 at 10 µM but does inhibit ShHTL8 and ShHTL11 (IC50s = 1.2 and 7.8 µM, respectively). SPL7 induces S. hermonthica seed germination in the absence of a host, which is fatal to this obligate parasite, with a minimum effective concentration of 10 fM. It induces suicidal germination of S. hermonthica seeds and decreases the number of plants emerging from the soil, as well as reduces S. hermonthica-induced senescence in maize plants when pre-applied to the soil of co-cultivated maize plants and S. hermonthica seeds at a concentration of 10 nM.  

 

Available on backorder

Add to quotes
SKU: 26922 - 10 mg Category:

Description

An agonist of S. hermonthica ShHTL7; binds to ShHTL7 (IC50 = 0.31 µM) over ShHTL2-6, ShHTL9-1, and the strigolactone receptor AtD14 at 10 µM but does inhibit ShHTL8 and ShHTL11 (IC50s = 1.2 and 7.8 µM, respectively); induces fatal S. hermonthica seed germination (MEC = 10 fM); induces suicidal germination of S. hermonthica seeds and decreases the number of plants emerging from the soil, as well as reduces S. hermonthica-induced senescence in maize plants when pre-applied to the soil of co-cultivated maize plants and S. hermonthica seeds at 10 nM

Formal name: 4-[(4-butoxyphenyl)sulfonyl]-1-piperazinecarboxylic acid, 2,5-dihydro-4-methyl-5-oxo-2-furanyl ester

Synonyms:  SPL7​

Molecular weight: 438.5

CAS: 2305752-57-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Plant Biology|Plant Growth Regulators

Related products

  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 50 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 50 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 10 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 1 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 1 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 100 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 100 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page