A polyphenol fungal metabolite originally isolated from Alternaria that has diverse biological activities; an inhibitor of Src (IC50 = 20 nM); inhibits fibrillization of recombinant tau fragments in vitro; inhibits phosphorylation of tau in SH-SY5Y cells expressing human P301L mutant tau at 10 μM; an FXR agonist (EC50 = 3.2 μM); reduces blood glucose

Altenusin – 5 mg

Brand:
Cayman
CAS:
31186-12-6
Storage:
-20
UN-No:
Non-Hazardous - /

Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.{47219,47220} It inhibits Src kinase with an IC50 value of 20 nM.{47221} Altenusin inhibits fibrillization of recombinant tau fragments in vitro and phosphorylation of tau in SH-SY5Y cells expressing human P301L mutant tau when used at a concentration of 10 μM.{47219} It is an agonist of the farnesoid X receptor (FXR; EC50 = 3.2 μM) that reduces blood glucose, serum insulin, and serum cholesterol levels, as well as hepatic lipogenic gene expression and steatosis, in a high fat diet-induced mouse model of obesity when administered at 30 mg/kg per day.{47220} Altenusin also has antioxidant and antifungal properties.  

 

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SKU: 26911 - 5 mg Category:

Description

A polyphenol fungal metabolite originally isolated from Alternaria that has diverse biological activities; an inhibitor of Src (IC50 = 20 nM); inhibits fibrillization of recombinant tau fragments in vitro; inhibits phosphorylation of tau in SH-SY5Y cells expressing human P301L mutant tau at 10 μM; an FXR agonist (EC50 = 3.2 μM); reduces blood glucose, serum insulin, and serum cholesterol levels, as well as hepatic lipogenic gene expression and steatosis, in a high fat diet-induced mouse model of obesity at 30 mg/kg; has antioxidant and antifungal properties

Formal name: 3,4′,5′-trihydroxy-5-methoxy-2′-methyl-[1,1′-biphenyl]-2-carboxylic acid

Synonyms:  Alutenusin

Molecular weight: 290.3

CAS: 31186-12-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Endocrinology & Metabolism|Hormones & Receptors|FXRs & LXRs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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