A flavonoid with diverse biological activities; induces apoptosis in and reduces cell viability of PATU-8988 and PANC-1 pancreatic cancer cells; reduces expression of COX-2

Isoorientin – 25 mg

Brand:
Cayman
CAS:
4261-42-1
Storage:
-20
UN-No:
Non-Hazardous - /

Isoorientin is a flavonoid that has been found in G. olivieri and has diverse biological activities.{47348,47349,47350} It induces apoptosis in and reduces cell viability of PATU-8988 and PANC-1 pancreatic cancer cells in a concentration-dependent manner.{47348} Isoorientin reduces expression of COX-2, IL-6, 5-lipoxygenase (5-LO), and TNF-α in RAW 264.7 cells.{47349} In vivo, isoorientin (20 mg/kg) reduces carrageenan-induced paw edema and air pouch blood vessel swelling in mice. It increases stomach levels of superoxide dismutase (SOD) and glutathione (GSH) and reduces ulcer area in a rat model of gastric ulcers induced by indomethacin (Item No. 70270).{47350}  

 

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SKU: 26862 - 25 mg Category:

Description

A flavonoid with diverse biological activities; induces apoptosis in and reduces cell viability of PATU-8988 and PANC-1 pancreatic cancer cells; reduces expression of COX-2, IL-6, 5-LO, and TNF-α in RAW 264.7 cells; reduces carrageenan-induced paw edema and air pouch blood vessel swelling in mice at 20 mg/kg; increases stomach levels of SOD and GSH and reduces ulcer area in a rat model of indomethacin-induced gastric ulcers

Formal name: 2-(3,4-dihydroxyphenyl)-6-β-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one

Synonyms:  Homoorientin|Lespecapitioside|Lutonaretin

Molecular weight: 448.4

CAS: 4261-42-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation|Gastric Disease|Peptic Ulcers||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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