A diterpene with diverse biological activities; inhibits proliferation in a variety of cancer cell lines

Tanshinone I – 10 mg

Brand:
Cayman
CAS:
568-73-0
Storage:
-20
UN-No:
Non-Hazardous - /

Tanshinone I is a diterpene that has been found in S. miltiorrhiza and has diverse biological activities, including anticancer, antidiabetic, and neuroprotective properties.{43902,43903,43904,43905} It inhibits proliferation in a variety of cancer cell lines, including KB/VCR, MCF-7/ADR, and K562/A02 multidrug resistance cell lines.{43903} It inhibits topoisomerase I- and topoisomerase II-mediated supercoiled DNA relaxation activity when used at concentrations of 200 and 25 µM, respectively. Tanshinone I also inhibits proliferation of H358-IR and H157-IR radioresistant lung cancer cells (IC50s = 10.87 and 6.1 µM, respectively) and sensitizes them to radiation.{43904} It reduces plasma levels of total cholesterol, triglycerides, LDL, and nonesterified fatty acids and decreases blood glucose levels in a rat model of type 2 diabetes induced by streptozotocin (Item No. 13104) and a high-fat diet.{43906} Tanshinone I reduces the LPS-induced expression of TNF-α, IL-1β, and IL-6 in microglia in vitro.{43905} It is neuroprotective in a mouse model of Parkinson’s disease induced by MPTP, preventing dopaminergic cell death in the striatum and improving motor function when administered at a dose of 10 mg/kg per day for two weeks.  

 

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Description

A diterpene with diverse biological activities; inhibits proliferation in a variety of cancer cell lines, including multidrug-resistance cell lines; inhibits topoisomerase I- and topoisomerase II-mediated supercoiled DNA relaxation activity at 200 and 25 µM, respectively; inhibits proliferation of H358-IR and H157-IR radioresistant lung cancer cells (IC50s = 10.87 and 6.1 µM, respectively); reduces plasma levels of total cholesterol, triglycerides, LDL, and nonesterified fatty acids and decreases blood glucose levels in a rat model of streptozotocin and high-fat diet-induced type 2 diabetes; neuroprotective in an MPTP mouse model of Parkinson’s disease at 10 mg/kg per day for two weeks

Formal name: 1,6-dimethyl-phenanthro[1,2-b]furan-10,11-dione

Synonyms:  Tanshinone A

Molecular weight: 276.3

CAS: 568-73-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|DNA Damage and Repair|Topoisomerase||Research Area|Cancer|Multidrug Resistance||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Neuroscience|Neuroprotection

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