A sesquiterpene alcohol with diverse biological activities; a PAM of GABAA receptors that potentiates GABA-induced currents in hippocampal neurons; reduces activation of proinflammatory NF-κB and profibrotic TGF-β1/SMAD signaling pathways in RAW 264.7 cells stimulated with cigarette smoke extract from 1-200 μg/ml; inhibits proliferation of and induces apoptosis in LoVo and SW480 colorectal cancer cells; reduces tumor volume in a LoVo mouse xenograft model from 20-80 mg/kg; increases the rate of wound closure in rats with streptozotocin-induced diabetes

Curcumol – 100 mg

Brand:
Cayman
CAS:
4871-97-0
Storage:
-20
UN-No:
Non-Hazardous - /

Curcumol is a sesquiterpene alcohol that has been found in Curcumae oil and has diverse biological activities.{48354,48355,48356,48357} It is a positive allosteric modulator (PAM) of GABAA receptors that potentiates GABA-induced currents in the presence of the benzodiazepine GABA agonist diazepam, but not the GABAA PAM (–)-menthol, in mouse hippocampal neurons.{48354} Curcumol (1-200 μg/ml) reduces activation of proinflammatory NF-κB and profibrotic TGF-β1/SMAD signaling pathways in RAW 264.7 cells stimulated with cigarette smoke extract.{48355} It inhibits proliferation of and induces apoptosis in LoVo and SW480 colorectal cancer cells in a concentration-dependent manner.{48356} In vivo, curcumol (20-80 mg/kg) reduces tumor volume in a LoVo mouse xenograft model. Curcumol also increases the rate of wound closure in rats with diabetes induced by streptozotocin (Item No. 13104).{48357}  

 

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Description

A sesquiterpene alcohol with diverse biological activities; a PAM of GABAA receptors that potentiates GABA-induced currents in hippocampal neurons; reduces activation of proinflammatory NF-κB and profibrotic TGF-β1/SMAD signaling pathways in RAW 264.7 cells stimulated with cigarette smoke extract from 1-200 μg/ml; inhibits proliferation of and induces apoptosis in LoVo and SW480 colorectal cancer cells; reduces tumor volume in a LoVo mouse xenograft model from 20-80 mg/kg; increases the rate of wound closure in rats with streptozotocin-induced diabetes

Formal name: (3S,3aS,5S,6R,8aS)-octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6H-3a,6-epoxyazulen-6-ol

Synonyms:  (−)-Curcumol

Molecular weight: 236.4

CAS: 4871-97-0

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience

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