A 5-nitroimidazole derivative with antibacterial and antiprotozoal activities; inhibits the growth of clinical isolates of B. fragilis (MICs = 0.5-5 μM) and various anaerobic bacteria from Giardia isolates (IC50s = 0.01-0.47 μg/ml); oral administration reduces T. vaginalis and T. foetus infection in mice and E. histolytica infection in rats (CD50s = 37

Ornidazole – 5 g

Brand:
Cayman
CAS:
16773-42-5
Storage:
-20
UN-No:
Non-Hazardous - /

Ornidazole is an orally bioavailable 5-nitroimidazole derivative with antibacterial and antiprotozoal activities.{35717,26702} Ornidazole inhibits the growth of clinical isolates of B. fragilis (MICs = 0.5-5 μM) and various anaerobic bacteria when used at concentrations ranging from less than 0.1 to 3.2 μg/ml.{26702,48267} It also inhibits the growth of Giardia isolates (IC50s = 0.01-0.47 μg/ml).{48268} Oral administration of ornidazole reduces T. vaginalis and T. foetus infection in mice and E. histolytica infection in rats with curative dose (CD50) values of 37, 3, and 10 mg/kg, respectively.{35717} Ornidazole (400 mg/kg per day) induces infertility in male rats within 7 days and inhibits spermatozoa binding to rat oocyte zona pellucida.{48269,48270}  

 

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SKU: 26818 - 5 g Category:

Description

A 5-nitroimidazole derivative with antibacterial and antiprotozoal activities; inhibits the growth of clinical isolates of B. fragilis (MICs = 0.5-5 μM) and various anaerobic bacteria from Giardia isolates (IC50s = 0.01-0.47 μg/ml); oral administration reduces T. vaginalis and T. foetus infection in mice and E. histolytica infection in rats (CD50s = 37, 3, and 10 mg/kg, respectively); induces infertility in male rats at 400 mg/kg

Formal name: α-(chloromethyl)-2-methyl-5-nitro-1H-imidazole-1-ethanol

Synonyms:  (±)-Ornidazole|NSC 95075|Ro 7-0207

Molecular weight: 219.6

CAS: 16773-42-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Parasitic Diseases|Giardiasis||Research Area|Infectious Disease|Parasitic Diseases|Trichomoniasis

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