An inhibitor of VMAT2 (Kis = 110 and 150 nM in rat striatum homogenates and human platelets

Valbenazine – 5 mg

Brand:
Cayman
CAS:
1025504-45-3
Storage:
-20
UN-No:
Non-Hazardous - /

Valbenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2; Kis = 110 and 150 nM in rat striatum homogenates and human platelets, respectively).{47247} It is selective for VMAT2 over a panel of 80 receptors, transporters, and ion channels, including the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, and 5-HT2B and dopamine D1 and D2 receptors. Valbenazine induces ptosis in rats, indicating norepinephrine depletion. Formulations containing valbenazine have been used in the treatment of tardive dyskinesia.  

 

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SKU: 26809 - 5 mg Category:

Description

An inhibitor of VMAT2 (Kis = 110 and 150 nM in rat striatum homogenates and human platelets, respectively); selective for VMAT2 over a panel of 80 receptors, transporters, and ion channels; increases ptosis in rats

Formal name: L-valine, (2R,3R,11bR)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-yl ester

Synonyms:  NBI-98854

Molecular weight: 418.6

CAS: 1025504-45-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Behavioral Neuroscience

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