An anticancer compound; inhibits proliferation in a panel of melanoma and breast

CAY10735 – 1 mg

Brand:
Cayman
CAS:
2251753-58-7
Storage:
-20
UN-No:
Non-Hazardous - /

CAY10735 is an anticancer compound.{48452} It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mesenchymal transition (EMT) in A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of reactive oxygen species (ROS) in these cells in a concentration-dependent manner. CAY10735 (5 mg/kg) reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model.  

 

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SKU: 26753 - 1 mg Category:

Description

An anticancer compound; inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM); inhibits migration of and EMT in A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner; reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of ROS in these cells in a concentration-dependent manner; reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model at 5 mg/kg

Formal name: N-[2-[[[1-[[(4-fluorophenyl)amino]carbonyl]cyclopropyl]carbonyl]amino]ethyl]-2-methylene-3-oxo-olean-12-en-28-amide

Synonyms: 

Molecular weight: 714

CAS: 2251753-58-7

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Research Area|Cancer|Cell Migration & Metastasis

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