Description
An antagonist of CCR5, CCR2b, and CXCR3; inhibits CCR5 and CXCR3 (IC50s = 236 and 369 nM, respectively) and CCR5 and CCR2b (IC50s = 1.4 and 27 nM, respectively); inhibits the replication of clinical isolates of R5, but not X4, HIV-1 in human PBMCs (EC50s = 1.6-3.5 and >20,000 nM, respectively); inhibits ovalbumin-induced increases in CCR5, CXCR3, IFN-γ, and TNF-α expression in mouse lung, as well as the number of total cells, lymphocytes, and eosinophils in BALF, in a mouse model of asthma at 250 mg per animal per day; increases intestinal allograft survival in a rat model of small intestine transplantation at 10 mg/kg per day
Formal name: N-[[4-[[[6,7-dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-2H-pyran-4-aminium, monochloride
Synonyms:
Molecular weight: 531.1
CAS: 229005-80-5
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antivirals|CCR5 Receptor Antagonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS
