A potent PDE4D inhibitor (IC50 = 3 nM); selective for PDE4D over PDE4A

CP 671,305 – 1 mg

Brand:
Cayman
CAS:
445295-04-5
Storage:
-20
UN-No:
Non-Hazardous - /

CP 671,305 is a potent inhibitor of phosphodiesterase 4D (PDE4D; IC50 = 3 nM).{46489} It is selective for PDE4D over PDE4A, -B, and -C (IC50s = 310, 287, and 3,858 nM, respectively), as well as over PDE1-3 and 5 (IC50s = >5,000 nM for all). CP 671,305 inhibits release of leukotriene E4 (LTE4; Item No. 20410) from eosinophils (IC50 = 52 nM) and LTB4 (Item No. 20110) from neutrophils (IC50 = 106 nM). In vivo, CP 671,305 inhibits antigen-induced pulmonary eosinophil influx in cynomolgus monkeys in a dose-dependent manner.  

 

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SKU: 26743 - 1 mg Category:

Description

A potent PDE4D inhibitor (IC50 = 3 nM); selective for PDE4D over PDE4A, -B, and -C (IC50s = 310, 287, and 3,858 nM, respectively), as well as over PDE1-3 and 5 (IC50s = >5,000 nM for all); inhibits release of LTE4 from eosinophils (IC50 = 52 nM) and LTB4 from neutrophils (IC50 = 106 nM); inhibits antigen-induced pulmonary eosinophil influx in cynomolgus monkeys in a dose-dependent manner

Formal name: (2R)-2-[4-[[[[2-(1,3-benzodioxol-5-yloxy)-3-pyridinyl]carbonyl]amino]methyl]-3-fluorophenoxy]-propanoic acid

Synonyms: 

Molecular weight: 454.4

CAS: 445295-04-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cell Biology||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity

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