Triacontanoic acid methyl ester is a fatty acid methyl ester that has been found in sediment samples from the Harney River in Florida and Lake Kivu in the East African rift valley.{38856,38863} [Matreya, LLC. Catalog No. 1273]
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A fatty acid methyl ester; has been found in sediment samples from the Harney River in Florida and Lake Kivu in the East African rift valley ,
Formal name: triacontanoic acid, methyl ester
Synonyms: C30:0 methyl ester|Methyl Melissate|Methyl Triacontanoate|NSC 20743
Molecular weight: 466.8
CAS: 629-83-4
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Lipids|Fatty Esters/Ethers||Research Area|Lipid Biochemistry|Fatty Acids
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}
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The maintenance of embryonic stem cells in culture typically requires feeder cells and various exogenous factors found in serum. Murine embryonic stem (mES) cells can be maintained in the absence of feeder cells and serum but require the leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) to prevent differentiation and promote self-renewal. SC-1 is a small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state.{14533} The activity of SC-1 is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.{14533} Inhibition of RasGAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK blocks differentiation.
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