A protease inhibitor; inhibits thrombokinase

Antipain (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
37682-72-7
Storage:
-20
UN-No:
Non-Hazardous - /

Antipain is a protease inhibitor originally isolated from actinomycetes.{45118} It inhibits thrombokinase, plasmin, trypsin, and papain in vitro (IC50s = 20, 93, 0.26, and 0.16 μg/ml, respectively). Antipain (6-600 μg/ml) inhibits the morphological transformation of and increases frequency of chromosomal aberrations in Syrian hamster embryo cells induced by N-methyl-N’-nitro-N-nitroso-guanidine (MNNG).{45119} In vivo, antipain (25-100 mg/kg) suppresses urethan-induced formation of cleft palates and cleft lips in mice.{45120}  

 

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SKU: 26705 - 5 mg Category:

Description

A protease inhibitor; inhibits thrombokinase, plasmin, trypsin, and papain in vitro (IC50s = 20, 93, 0.26, and 0.16 μg/ml, respectively); inhibits the MNNG-induced morphological transformation of and increases frequency of chromosomal aberrations in Syrian hamster embryo cells from 6-600 μg/ml; suppresses urethan-induced formation of cleft palates and cleft lips in mice from 25-100 mg/kg

Formal name: N2-[[[(1S)-1-carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-valinamide, dihydrochloride

Synonyms: 

Molecular weight: 677.6

CAS: 37682-72-7

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Cell Biology|Proteolysis|Lysosomal Proteases||Research Area|Toxicology|Cell Health & Viability

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