A mycotoxin anthelmintic; binds to acetylcholine receptors (IC50 = 0.5 nM); toxic to C. elegans (LD50 = 2.5 µg/ml) and effective against T. colubriformis infection in gerbils at 0.39-200 mg/kg; toxic to mice (LD50 = 14.9 mg/kg)

Paraherquamide A – 1 mg

Brand:
Cayman
CAS:
77392-58-6
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Paraherquamide A is a mycotoxin anthelmintic originally isolated from P. paraherquei.{47167} It binds to acetylcholine receptors (IC50 = 0.5 nM for head homogenates of M. domestica) and acts as an antagonist.{47167,47168} Paraherquamide A is toxic to C. elegans (LD50 = 2.5 µg/ml) and effective against T. colubriformis infection in gerbils when used at doses ranging from 0.39 to 200 mg/kg.{47169,47170} It is toxic to mice (LD50 = 14.9 mg/kg).{47171}  

 

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SKU: 26685 - 1 mg Category:

Description

A mycotoxin anthelmintic; binds to acetylcholine receptors (IC50 = 0.5 nM); toxic to C. elegans (LD50 = 2.5 µg/ml) and effective against T. colubriformis infection in gerbils at 0.39-200 mg/kg; toxic to mice (LD50 = 14.9 mg/kg)

Formal name: (1’R,5’aS,7’R,8’aS,9’aR)-2′,3′,8’a,9′-tetrahydro-1′-hydroxy-1′,4,4,8′,8′,11′-hexamethyl-spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,7′(8’H)-[5H,6H-5a,9a](iminomethano)[1H]cyclopent[f]indolizine]-9,10′(10H)-dione

Synonyms:  (–)-Paraherquamide|VM 29919

Molecular weight: 493.6

CAS: 77392-58-6

Purity: ≥95%

Formulation: A powder

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases

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