An internal standard for the quantification of noscapine by GC- or LC-MS

Noscapine-13C-d3 – 1 mg

Brand:
Cayman
CAS:
1217680-57-3
Storage:
-20
UN-No:
Non-Hazardous - /

Noscapine-13C-d3 is intended for use as an internal standard for the quantification of noscapine (Item No. 17255) by GC- or LC-MS. Noscapine is an alkaloid that has been found in opium and has anticancer and antitussive properties.{28232,28233,49588} It binds to tubulin and induces cell cycle arrest at the G2/M phase in HeLa cells when used at a concentration of 20 µM.{28233} Noscapine induces apoptosis in HeLa cells and thymocytes (IC50s = 25 and 10 µM, respectively) and reduces proliferation of MCF-7 breast and Renal 1983 bladder cancer cells (IC50s = 42.3 and 39.1 µM, respectively). In vivo, noscapine (120 mg/kg) induces tumor regression in an MCF-7 mouse xenograft model. Noscapine (30 and 70 mg/kg) decreases the number of citric acid-induced coughs in guinea pigs.{49588}  

 

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Description

An internal standard for the quantification of noscapine by GC- or LC-MS

Formal name: (3S)-6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-13C-d3-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone

Synonyms:  Narcotine-13C-d3|Opianine-13C-d3

Molecular weight: 417.4

CAS: 1217680-57-3

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|13C||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation|Adaptive Immunity

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