A cationic cholesterol derivative; has been used in lipoplexes with DOPE for siRNA delivery and gene silencing in MCF-7 cells as well as in mice via intravenous injection

OH-Chol – 10 mg

Brand:
Cayman
CAS:
191173-82-7
Storage:
-20
UN-No:
Non-Hazardous - /

OH-Chol is a cationic cholesterol derivative.{45145} OH-Chol, as a component of lipoplexes with DOPE (Item No. 15091), has been used for siRNA delivery and gene silencing in MCF-7 cells, as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver. It has also been used in cationic nanoparticles in combination with Tween 80 to transfect pDNA and siRNA into PC3 mouse xenografts via intratumoral injection and with Tween 80 and folate-PEG2000-DSPE in a KB mouse xenograft model for intratumoral gene delivery.{45299}  

 

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SKU: 26586 - 10 mg Category:

Description

A cationic cholesterol derivative; has been used in lipoplexes with DOPE for siRNA delivery and gene silencing in MCF-7 cells as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver; has been used in cationic nanoparticles in combination with Tween 80 to transfect pDNA and siRNA into PC3 mouse xenografts via intratumoral injection; has been used in cationic nanoparticles in combination with Tween 80 and folate-PEG2000-DSPE in a KB mouse xenograft model for intratumoral gene delivery

Formal name: N-[2-[(2-hydroxyethyl)amino]ethyl]-(3β)-cholest-5-ene-3-carboxamide

Synonyms: 

Molecular weight: 500.8

CAS: 191173-82-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Cell Biology||Research Area|Lipid Biochemistry

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