A turn-on fluorescent probe to detect hypoxia; transformed into a highly fluorescent molecule in the presence of nitroreductase

CAY10730 – 10 mg

Brand:
Cayman
CAS:
2206677-06-5
Storage:
-20
UN-No:
Non-Hazardous - /

CAY10730 is a turn-on fluorescent probe for the detection of nitroreductase activity, a marker of hypoxia.{48243} In the presence of nitroreductase, CAY10730 is transformed into a highly fluorescent molecule that displays excitation/emission maxima of 454/520 nm, respectively. It is selective for nitroreductase over a variety of bioanalytes, including glutathione, ascorbic acid, and reactive oxygen species such as H2O2. CAY10730 (1 µM) has been used to detect hypoxia in A549 human lung carcinoma cells.  

 

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SKU: 26547 - 10 mg Category:

Description

A turn-on fluorescent probe to detect hypoxia; transformed into a highly fluorescent molecule in the presence of nitroreductase, a marker of hypoxia; selective for nitroreductase over a variety of bioanalytes, including glutathione, ascorbic acid, and H2O2; has been used to detect hypoxia in A549 human lung carcinoma cells at 1 µM; ex/em = 454/520 nm, respectively

Formal name: 3′-methoxy-6′-[(4-nitrophenyl)methoxy]-spiro[isobenzofuran-1(3H),9′-[9H]xanthen]-3-one

Synonyms: 

Molecular weight: 481.5

CAS: 2206677-06-5

Purity: ≥98%

Formulation: A crystalline solid

Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Cancer|Tumor Microenvironment||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling

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